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SUMMARY: Working with and across the Lead Discovery Department, the Scientist III is responsible for assay development, optimization and completion of HTS assays (1536-well plate format) to support the hit identification effort in early-stage projects. This scientist is also responsible for the development and execution of diverse biochemical and cellular assays to profile compound mechanism of action and structure activity relationship (96-and 384-well plate formats) to advance research programs from discovery to development candidate nomination.
ESSENTIAL DUTIES AND RESPONSIBILITIES:
- Develops and optimizes (under guidance from supervisor) and executes (independently) compound profiling and projects focused on the targeting and interrogation of signaling pathways with a general knowledge of current approaches focused on hit and lead identification.
- Develops, evaluates, optimizes and implements new technologies, laboratory protocols, and methodologies for biochemical and cell-based assays to meet project goals and objectives.
- Presents data and reports on project status at department/ group meetings.
- Communicates scientific results and publishes data to company databases.
- Interacts and collaborates with internal groups and departments to discuss and resolve program and/or department needs.
- Applies advanced scientific and technical principles, theories and concepts. Contributes to the development of new principles and concepts.
- Responds to common inquiries or complaints from customers, regulatory agencies, or members of the business/scientific communities.
- Maintains laboratory notebook in a complete, consistent and concise manner in accordance with company intellectual property policies and practices.
- Complies with company health and safety policies and general laboratory practices.
EDUCATION/EXPERIENCE/SKILLS:
Education:
- BS in related discipline and a minimum of five years of related experience; or,
- MS degree in related discipline and a minimum of three year of related experience; or.
- Equivalent combination of education and experience.
Experience:
- Experience in an HTS laboratory operating automation equipment (e.g., liquid handlers, dispensers), is essential. Extensive experience in assay development for HTS applications, conducting screening campaigns, lead validation, lead optimization is preferred.
- Experience in a variety of kinase, enzymatic and cell-based assays in oncology therapeutics is required.
- Excellent data analysis skills and experience with a variety of scientific software applications (e.g., GraphPad Prism, Activity Base, Genedata) is preferred.
Knowledge/Skills/Abilities:
- General understanding of cellular and biochemical assays as well as the detection technologies used in their execution.
- Ability to collaborate with a cross-functional team.
- Ability to multi-task in a fast-paced dynamic environment while delivering high quality work.
- General understanding of how the individual experiments fit within a larger research program to meet organizational goals.
- General understanding and application of scientific principles, theories and concepts in field of specialty and other related disciplines.
- Ability to apply a variety of cutting-edge automation tools (liquid handlers, readers, etc.) to enable cellular assays.
- In discussion with management, sets goals with understanding of priority and impact to the program, department and organization.
- Ability to read, analyze and interpret common scientific and technical journals, financial reports and legal documents.
- Excellent interpersonal and written communication skills.
JOB COMPLEXITY:
- Works on extremely complex problems under supervision where analysis of situations or data requires an evaluation of intangible variables.
- Exercises independent judgment in developing methods, techniques and evaluation criteria for obtaining results.
- Uses professional concepts to contribute to the development of company concepts and principles and to achieve objectives in creative and effective ways.
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If you like wild growth and working with happy, enthusiastic over-achievers, you'll enjoy your career with us!
Our compensation reflects the cost of labor across severalU.S. geographic markets, and we pay differently based on those defined markets. The base pay range for this positionis $100,000 - $141,500 annually. The base pay range may take into account the candidate's geographic region, which will adjust the pay depending on the specific work location. The base pay offered will take into account the candidate's geographic region, job-related knowledge, skills, experience and internal equity, among other factors.In addition to the base salary, as part of our Total Rewards program, Exelixis offers comprehensive employee benefits package, including a 401k plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. Employees are also eligible for a discretionary annual bonus program, or if field sales staff, a sales-based incentive plan. Exelixis also offers employees the opportunity to purchase company stock, and receive long-term incentives, 15 accrued vacation days in their first year, 17 paid holidays including a company-wide winter shutdown in December, and up to 10 sick days throughout the calendar year.DISCLAIMER
The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.
We are an Equal Opportunity Employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, and basis of disability or any other federal, state or local protected class.